Many states have legalized cannabis (marijuana) for medical use and for recreational purposes. Despite this rise in social and legal acceptance, public health concerns regarding the use of cannabis remain, especially among dental professionals. Cannabis has been promoted as an adjunct to local anesthetic agents in the management of peri-operative pain and as a replacement for nitrous oxide in the management of peri-operative anxiety. It has also been promoted as an adjunct to non-opioid analgesics and opioid analgesics in the management of postoperative dental pain and even as an adjunct to Medication-Assisted Treatment (MAT) for opioid and other addictions. This two-hour course will provide an overview of the use of local anesthetic agents, and non-opioid and opioid analgesics in the management of peri-operative and post-operative dental pain and will explore the rationale for the potential use of cannabis in dentistry.